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国内做的好网站有哪些,网站建设生意怎么样,站长统计 wordpress,可以做商城网站的公司BAM15#xff08;AbMole#xff0c;M8653#xff09;是一种新型合成的线粒体解偶联剂#xff0c;可破坏电子传递链与ATP合成之间的质子梯度。其作用原理如下#xff1a;BAM15具有离子载体的特性#xff0c;可在双层脂膜中诱导质子传导#xff0c;导致跨线粒体内膜的质子…BAM15AbMoleM8653是一种新型合成的线粒体解偶联剂可破坏电子传递链与ATP合成之间的质子梯度。其作用原理如下BAM15具有离子载体的特性可在双层脂膜中诱导质子传导导致跨线粒体内膜的质子梯度消失增加活性氧积累并抑制细胞增殖和迁移[1]。上述效应已在人乳腺癌细胞系MDA-MB-231和小鼠乳腺癌细胞系EO771中得到验证[2]。此外BAM15AbMoleM8653通过抑制线粒体的功能还可调控巨噬细胞极化在RAW264.7小鼠巨噬细胞中显著抑制促炎性M1型极化同时促进抗炎性M2型标志基因表达[3]。在动物实验中C57BL/6J小鼠经BAM15干预后表现出显著的体重控制效果同时伴随糖代谢改善和肝脏脂肪沉积减少[4]。BAM15的纳米颗粒形式以PLGA作为载体在LPSLipopolysaccharides脂多糖 诱导的脓毒症小鼠模型中显示该纳米粒子可被脾脏和肝脏巨噬细胞特异性摄取减轻全身炎症反应并保护肝损伤[3]。BAM15还被用于增强CD7CAR-T细胞的抗肿瘤功能在异种移植小鼠模型中低浓度的BAM15即可提升细胞毒性并降低细胞因子释放[5]。*本文所述产品仅供科研使用参考文献及鸣谢[1] Firsov, A. M.; Popova, L. B.; Khailova, L. S.; et al. Protonophoric action of BAM15 on planar bilayers, liposomes, mitochondria, bacteria and neurons. Bioelectrochemistry (Amsterdam, Netherlands)2021, 137, 107673.[2] Zunica, E. R. M.; Axelrod, C. L.; Cho, E.; et al. Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer metabolism2021, 9 (1), 36.[3] Udompornpitak, K.; Bhunyakarnjanarat, T.; Saisorn, W.; et al. Polymeric Particle BAM15 Targeting Macrophages Attenuates the Severity of LPS-Induced Sepsis: A Proof of Concept for Specific Immune Cell-Targeted Therapy. Pharmaceutics2023, 15 (12).[4] Axelrod, C. L.; King, W. T.; Davuluri, G.; et al. BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO molecular medicine2020, 12 (7), e12088.[5] Ma, Y.; Zhang, H.; Dou, L.; et al. Mitochondrial uncoupler BAM15 enhances the function of CD7CAR-T(CD7-) cells and reduces the release of cytokines for the therapy of T-cell malignancies. International immunopharmacology2025, 155, 114577.